The Methods for Biological Modeling Subgroup brings together those interested in the development of novel application of methods (e.g., numerical, analytical/theoretical, agent-based modeling, statistical, parameter estimation, identifiability, and machine learning) towards modeling biological systems. In applying standard methodologies, mathematical modelers encounter many challenges with simulating and analyzing biological systems, such as high dimensionality, computational complexity, observation or process error, model bias, and intra- and inter-individual heterogeneity. The objective of the subgroup is to support and disseminate new advances in tackling these challenges to the Mathematical Biology community. This subgroup was started in February 2020.